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CBD Expo Tour EAST 2019
November 16, 2019, Orlando, USA
CBD Expo Tour EAST 2019
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CBD Expo Tour EAST 2019
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The Entourage Effect Theory Of Cannabinoid Therapy
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  • Description
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About the talk

This presentation reviews the basic and laboratory model research supporting the need for a balanced stimulation of both CB1 and CB2 receptors in order to achieve homeostasis, repair defects of energy production, slow cell replication that otherwise might lead to cancer proliferation, and stabilize the immune system in humans. Furthermore, the use of measurable Biomarkers of disease progression and the mechanisms of Cannabinoid therapy of chronic disease pathogenesis can enhance and greatly speed the testing of whole-plant derived Cannabinoid therapies in diseases that develop over many years.

00:30 Entourage effect

06:10 Entourage effect and cannabinoid therapeutics’ developments

07:44 Endocannabinoid system

09:01 List of cannabinoid binding receptors

14:31 Intracellular pathways affected by CBR agonism

18:46 Biomarkers affected by CB1

21:49 CBR effects on immune cell maturation

23:31 PPARG pathway

25:34 TRPV receptors

27:22 TRP1 activated pathways

30:03 Other cannabinoids and anandamide like molecules

About speaker

David Ostrow
Director at David Ostrow & Associates

As a physician-scientist who is triple Board Certified in Psychiatry, Addiction and Cannabinoid Medicine, I have been an advocate for quality therapeutic research using wholeplant-derived (and laboratory quantified) cannabinoid extracts for 10+ years. As Vice President for Member Services of the Am Academy of Cannabinoid Medicine (AACM), I have been intimately involved in the organization of CME programs and a Certification Exam process for healthcare providers wanting to integrate Cannabinoid Medicine into their practices. Recognizing the important role that Cannabinoid Medicine can play in ending the epidemics of opioid and stimulant misuse, I have begun to organize a national Coalition to End Epidemics (CEDE) using medicinal cannabis and other Harm Reduction strategies. Recent slide presentations that are in the process of becoming manuscripts for publication include “The Entourage of Biomarkers that can be used to Understand and Research the Therapeutic Effects of Cannabinoids in Inflammation, Pain, Cancer and Neuropsychiatric Conditions” and “Cannabinoids and HIV,” both presented at the International Biomarkers Summit in Amsterdam, Oct 18-19th.

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