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Robert Davis
Senior Scientist at Treehouse Biotech
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CannaFarm CON 2019
August 1, 2019, San Diego, USA
CannaFarm CON 2019
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The Biosynthesis Of Cannabinoids And Beyond
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About speaker

Robert Davis
Senior Scientist at Treehouse Biotech

Robby is the recipient of a PhD in Organic Chemistry from Vanderbilt University, an MS in both Chemistry and Biochemistry from Villanova University, and a BS in Biology with Honors from James Madison University. Throughout his academic career his research interests and publishing focus ranged from microbiology and ecology to medicinal chemistry and natural product total synthesis.

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About the talk

Nature makes a huge diversity of compounds to use for all kinds of different reasons. We find this very useful much of the time on the cannabis plant. This session unveils the secrets of some compounds and biosynthesis.

00:23 Introduction

01:35 Why does nature make compounds?

04:09 Penicillin

05:18 Quinine powder

06:09 Why are some compounds useful to humans?

07:51 Cannabigerolic Acid (CBGa) biosynthesis

09:00 CBD, CBC, and THC

09:35 CBN and CBL

10:23 Why is THC produced?

11:28 Why are the other cannabinoids produced?

12:13 Genetically modified organisms

13:54 CRISPR

15:07 In summary

15:51 Q&A

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I see a lot of familiar faces from this morning, but just a quick recap. Work for a company called Treehouse Biotech where we're very interested in isolating a lot of the minor cannabinoid that very rare So by our count there are 113 individual cannabinoids to the isolated and then my group is really just kind of trying to get those isolated so we can look at them in pure forms in a cell line by logical systems figure out in unravel the whole puzzle what's going on here? So today in lieu of a title slide. I am just going to show you what we're going to talk about first. I wanted to do

just a quick overview of the sort of what I call chemical ecology. So nature makes compounds, in general, all over for lots of different reasons Apso lot of times. These are used for the people and Society finds some valuable it sorts of why that is endive. Moritz what we care about the cannabis plant, why does the plant make THC CBD other cannabinoids what's the value there and then sort of things I see coming down the line in the next 5 to 10 years that I could really change things and make things interesting. So without further Ado nature makes compounds. It's so

one example that we'll see you in a minute. Here is a bombardier beetle and that's a self-defense mechanism. That's really kind of mind-blowing on the another hand it why would nature make compounds besides a beetle trying to defend itself from being eaten a plant can't run away. So if they make some sort of poison or something really bitter so with you comes by to leave spits it out doesn't eat the plant again that sort of their only mode of

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